Classement Etats-Unis - MLS
| # | Equipe | MJ | V | N | D | Pour | Contre | Diff. | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | New England | 26 | 17 | 5 | 4 | 48 | 30 | +18 | 56 |
| 2 | Nashville SC | 24 | 10 | 11 | 3 | 39 | 23 | +16 | 41 |
| 3 | New York City | 24 | 11 | 5 | 8 | 43 | 28 | +15 | 38 |
| 4 | Orlando City | 25 | 10 | 8 | 7 | 36 | 36 | +0 | 38 |
| 5 | Montréal | 25 | 10 | 7 | 8 | 36 | 30 | +6 | 37 |
| 6 | Atlanta United | 25 | 9 | 9 | 7 | 35 | 30 | +5 | 36 |
| 7 | Philadelphia Union | 24 | 9 | 8 | 7 | 31 | 25 | +6 | 35 |
| 8 | D.C. United | 25 | 10 | 4 | 11 | 41 | 36 | +5 | 34 |
| 9 | Inter Miami | 24 | 9 | 5 | 10 | 24 | 35 | -11 | 32 |
| 10 | Columbus Crew | 26 | 8 | 7 | 11 | 30 | 35 | -5 | 31 |
| 11 | New York RB | 23 | 7 | 5 | 11 | 29 | 28 | +1 | 26 |
| 12 | Chicago Fire | 25 | 6 | 5 | 14 | 24 | 40 | -16 | 23 |
| 13 | Cincinnati | 24 | 4 | 8 | 12 | 24 | 44 | -20 | 20 |
| 14 | Toronto | 25 | 4 | 6 | 15 | 28 | 51 | -23 | 18 |
Calendrier Etats-Unis - MLS
| jeudi 23 septembre 2021 | ||
| Inter Miami | 00:30 | Nashville SC |
| New York RB | 01:00 | New York City |
| Chicago Fire | 01:00 | New England |
| samedi 25 septembre 2021 | ||
| Philadelphia Union | 20:30 | Atlanta United |
| dimanche 26 septembre 2021 | ||
| New England | 00:00 | Orlando City |
| D.C. United | 00:30 | Cincinnati |
| New York City | 00:30 | New York RB |
| Columbus Crew | 00:30 | Montréal |
| Minnesota United | 01:00 | Houston Dynamo |
| Colorado Rapids | 01:00 | Toronto |
| SJ Earthquakes | 03:00 | Los Angeles |
| Vancouver Whitecaps FC | 03:00 | Dallas |
| Portland Timbers | 03:30 | Real Salt Lake |
| Chicago Fire | 18:00 | Nashville SC |
| lundi 27 septembre 2021 | ||
| Sporting KC | 00:00 | Seattle Sounders |
| Austin | 02:30 | LA Galaxy |
Résultats Etats-Unis - MLS
| lundi 20 septembre 2021 | ||
| Colorado Rapids | 1 - 1 | Vancouver Whitecaps FC |
| Portland Timbers | 2 - 1 | Los Angeles |
| dimanche 19 septembre 2021 | ||
| Philadelphia Union | 3 - 1 | Orlando City |
| Montréal | 2 - 0 | Chicago Fire |
| Real Salt Lake | 1 - 0 | Seattle Sounders |
| Houston Dynamo | 3 - 2 | Dallas |
| Austin | 3 - 4 | SJ Earthquakes |
| Minnesota United | 3 - 0 | LA Galaxy |
| Cincinnati | 1 - 2 | New York City |
| Toronto | 2 - 1 | Nashville SC |
| New England | 1 - 1 | Columbus Crew |
| samedi 18 septembre 2021 | ||
| Atlanta United | 3 - 2 | D.C. United |
| Inter Miami | 0 - 4 | New York RB |